Novel cholecystokinin receptor ligands: Oxopiperazines derived from Boc-CCK-4
| Autor: | Elizabeth Alice Mathews, M. Szelke, Andrzej R Batt, David P Rooker, Hamish Ryder, David A Kendrick, Graeme Semple |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Dipeptide
Stereochemistry Ligand digestive oral and skin physiology Organic Chemistry Clinical Biochemistry Pharmaceutical Science digestive system Biochemistry Cholecystokinin receptor Chemical synthesis chemistry.chemical_compound chemistry Gastrointestinal hormone Amide Drug Discovery medicine Molecular Medicine CCK-4 Molecular Biology hormones hormone substitutes and hormone antagonists Cholecystokinin medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:867-872 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80253-5 |
| Popis: | Replacement of the C-terminal dipeptide amide of Boc-CCK-4 (1) with oxopiperazines yields a series of weak CCK-receptor ligands. Further modifications result in more potent and receptor subtype selective compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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