Radiolabeling and in-vivo distribution of nanobacteria in rabbits
| Autor: | Jyrki Parkkinen, Kari Åkerman, Jyrki T. Kuikka, Ilpo Kuronen, E. Olavi Kajander, Kim A. Bergstroem, Neva Ciftcioglu |
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| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science Planar Imaging medicine.diagnostic_test chemistry.chemical_element Single-photon emission computed tomography Technetium Calcifying Nanoparticles Nuclear magnetic resonance chemistry In vivo medicine Distribution (pharmacology) Preclinical imaging |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.278798 |
| Popis: | Nanobacteria are minute bacteria recently isolated from mammalian blood. They encapsulate themselves with apatite mineral.Cultured nanobacteria were radiolabeled with 'Tc, using a method which has been previously used for labeling red bloodcells with 99mTc and in vivo distribution of nanobacteria was followed with Single Photon Emission Computed Tomography(SPECT) imaging. The labeling yield was over 30%. Two rabbits were studied using dynamic planar imaging performed inthe AP-position immediately after injection. Serial SPECT scans were acquired up to 24 h and one planar image was taken at45 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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