Synthesis and biological evaluation of a bicyclo [7.4.1]enediyne

Autor:	Shyi-Long Lee, Wyle Solomon, A. Bain, Nada Zein, Gary A. Sulikowski
Rok vydání:	1996
Předmět:	Bicyclic molecule Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry chemistry.chemical_compound chemistry Drug Discovery Enediyne Molecular Medicine Molecular Biology DNA Biological evaluation
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:1261-1264
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00212-0
Popis:	The synthesis of bicyclo[7.4.1]enediynes 2a and 2b are described. The bicyclo[7.4.1]enediyne 2b was found to be a poor DNA cleaver but did cause damage to several protein isolates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c35f33028e7052d5c643957d5edf41f8 https://doi.org/10.1016/0960-894x(96)00212-0 Zobrazit plný text záznamu Full Text from ScienceDirect