Evaluation of Immunotoxicity of an Urban Profile of Nitrogen Dioxide: Acute, Subchronic, and Chronic Studies
| Autor: | Elaine C. Crose, MaryJane K. Selgrade, Mary J. Daniels |
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| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | Inhalation Toxicology. 3:389-403 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.3109/08958379109145297 |
| Popis: | Although a number of studies have demonstrated suppression of extrapulmonary immune responses following exposure to NO2, a ubiquitous ambient and indoor air pollutant, most of these studies have utilized extremely high concentrations of NO2 relative to the environment. Our intent was to assess effects of NO2 on extra-pulmonary immune responses using an environmentally relevant exposure regimen. Rats were exposed for 7, 3, 13, 52, or 78 wk to air or a pattern of NO2 designed to mimic episodic pollution in urban areas at concentrations 2–5 times those commonly seen in such areas. Daily exposures consisted of 0.5 ppm for 16 h, a 6-h exposure spike during which the concentration rose to 1.5 ppm, remained there for 2 h, and then returned to 0.5 ppm, and a 2-h down time. Rats were exposed to this profile 5 days/wk; weekend exposures did not include the spike. Blood was drawn and spleens were removed at the end of each exposure period. Spleen cells were assessed for natural killer (NK) cell activity and ... |
| Databáze: | OpenAIRE |
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