Narjatamanins A and B, a pair of novel epimers possessing a 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen bridge from Nardostachys jatamansi and evaluation of their effects on worm paralysis in AD C. elegans
| Autor: | Feng-Ming Qi, Zhi Dejuan, Ye Zhao, Zhan-Xin Zhang, Bing Li, Pan-Jie Su, Yi-Fan Yu, Chun-Xue Yu, Pei-Qian Wu, Dong-Qing Fei |
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| Rok vydání: | 2019 |
| Předmět: |
Circular dichroism
Iridoid biology Chemistry medicine.drug_class Stereochemistry General Chemical Engineering Nardostachys jatamansi 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Skeleton (computer programming) 0104 chemical sciences medicine Paralysis Epimer medicine.symptom 0210 nano-technology Two-dimensional nuclear magnetic resonance spectroscopy Caenorhabditis elegans |
| Zdroj: | RSC Advances. 9:24333-24337 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c9ra04485j |
| Popis: | Narjatamanins A (1) and B (2), a pair of epimers possessing a novel 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen bridge, were isolated from the whole plants of Nardostachys jatamansi. Their structures were elucidated by a combination of various spectroscopic methods, including HRESIMS, IR and 1D and 2D NMR techniques. The absolute configurations of 1 and 2 were established by electronic circular dichroism (ECD) calculations. The pharmacological activities of 1 and 2 to alleviate AD-like symptoms were also evaluated using the Caenorhabditis elegans Alzheimer's disease (AD) pathological model, and narjatamanins A (1) and B (2) showed statistically significant delay in the worm paralysis phenotype of AD-like symptoms. |
| Databáze: | OpenAIRE |
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