The Addition Reaction of Samarium Enolates and 2-Haloenolates Derived from Esters, and Amides to Imines. Totally Stereoselective Synthesis of Enantiopure 3,4-Diamino Esters or Amides

Autor:	Jose M. Concellon, M. Rosario Diaz, Vicente del Amo, Carmen Simal, Santiago García-Granda, Humberto Rodriguez‐Solla
Rok vydání:	2009
Předmět:	Samarium Addition reaction Enantiopure drug chemistry Magnesium chemistry.chemical_element Organic chemistry Lithium Stereoselectivity General Chemistry Racemization Mannich reaction
Zdroj:	Advanced Synthesis & Catalysis. 351:2991-3000
ISSN:	1615-4169 1615-4150
Popis:	The addition reaction of samarium enolates and 2-haloenolates derived from esters and amides to imines takes place in an efficient manner. A novel protocol to perform the addition reaction of samarium enolates derived from esters or amides to chiral 2-aminoimines, with total stereoselectivity and without racemization, is also reported. The use of samarium enolates in place of other classic metallic enolates (lithium, magnesium, etc.) could be a valuable alternative to obtain enantiopure 3,4-diamino esters or amides, when enolates of low basicity are necessary.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c350cfa1cdf4b5ecb76ade0b818bca5f https://doi.org/10.1002/adsc.200900534 Zobrazit plný text záznamu Plný text