ChemInform Abstract: Synthesis and Dopaminergic Activity of 2-Substituted Octahydrobenzo(f)quinolines

Autor:	P. R. Findell, Richard I. Weiner, J. C. Craig, S. M. Torkelson
Rok vydání:	1989
Předmět:	Chemistry Dopamine Stereochemistry Dopaminergic Radioligand medicine General Medicine Dopamine agonist medicine.drug
Zdroj:	ChemInform. 20
ISSN:	0931-7597
DOI:	10.1002/chin.198939192
Popis:	A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c34de88928efd92d83c339e66c71c6ed https://doi.org/10.1002/chin.198939192 Zobrazit plný text záznamu Plný text