Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers
| Autor: | Veronika Kozlovskaya, Hubert M. Tse, Eugenia Kharlampieva, Lilin He, William Higgins, Volker S. Urban, Aaron Alford, Dana Pham-Hua, Bing Xue, Nirzari Gupta |
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| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
Biocompatibility General Chemical Engineering medicine.medical_treatment 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Superoxide dismutase chemistry.chemical_compound Tannic acid Materials Chemistry medicine chemistry.chemical_classification Reactive oxygen species biology Chemistry General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Bioavailability Polyphenol biology.protein Biophysics 0210 nano-technology Oxidative stress |
| Zdroj: | Chemistry of Materials. 30:344-357 |
| ISSN: | 1520-5002 0897-4756 |
| Popis: | Local modulation of oxidative stress is crucial for a variety of biochemical events including cellular differentiation, apoptosis, and defense against pathogens. Currently employed natural and synthetic antioxidants exhibit a lack of biocompatibility, bioavailability, and chemical stability, resulting in limited capability to scavenge reactive oxygen species (ROS). To mediate these drawbacks, we have developed a synergistic manganoporphyrin-polyphenol polymeric nanothin coating and hollow microcapsules with efficient antioxidant activity and controllable ROS modulation. These materials are produced by multilayer assembly of a natural polyphenolic antioxidant, tannic acid (TA), with a synthesized copolymer of polyvinylpyrrolidone containing a manganoporphyrin modality (MnP-PVPON) which mimics the enzymatic antioxidant superoxide dismutase. The redox activity of the copolymer is demonstrated to dramatically increase the antioxidant response of MnP-PVPON/TA capsules versus unmodified PVPON/TA capsules throug... |
| Databáze: | OpenAIRE |
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