Safety of paracetamol during pregnancy: literature review

Autor:	O. A. Vartanova, M.V. Lukina, T B Andrushchishina, T E Morozova, I.A. Dronov, I.Yu. Yudina, M.A. Chukina
Rok vydání:	2020
Předmět:	Pregnancy medicine.medical_specialty Obstetrics business.industry Pediatrics Perinatology and Child Health medicine Obstetrics and Gynecology medicine.disease business
Zdroj:	Voprosy ginekologii, akušerstva i perinatologii. 19:96-101
ISSN:	2414-9152 1726-1678
DOI:	10.20953/1726-1678-2020-6-96-101
Popis:	Paracetamol (acetaminophen) is the drug of choice in pregnant women as an antipyretic and analgesic agent for various clinical conditions. However, long-term paracetamol administration during pregnancy was found to be associated with disorders in children, such as attention deficit hyperactivity disorder (RR = 1.32, 95% CI 1.18–1.45, I2 = 61%); autism spectrum disorders (RR = 1.23, 95% CI 1.13–1.32, I2 = 17%); hyperactivity disorder (RR = 1.24, 95% CI 1.02–1.46, I2 = 95%), and behavioral disorders (RR = 1.28, 95% CI 1.05–1.52, I2 = 94%). Studies conducted so far failed to identify the effect of paracetamol dose in different trimesters of pregnancy on the development of long-term functional disorders of the central nervous system in children. Further studies are needed to assess the importance of social factors and the environment and their contribution to the development of functional disorders of the central nervous system in children. Key words: acetaminophen, safety, pregnancy, neuropsychiatric development of children, paracetamol
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3441999a1f6771f70d57426b6d5a3f4 https://doi.org/10.20953/1726-1678-2020-6-96-101 Zobrazit plný text záznamu