Effects of administration of recombinant human interleukin-2 in dogs
| Autor: | R. Champlin, Nancy Taylor, G. R. Cain, Thomas G. Kawakami |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Hematology biology business.industry Lymphocyte Recombinant Human Interleukin-2 Pathology and Forensic Medicine law.invention Blood lymphocyte Endocrinology medicine.anatomical_structure law Internal medicine Recombinant DNA Dose group biology.protein Medicine Eosinophilia Anatomy medicine.symptom Antibody business |
| Zdroj: | Comparative Haematology International. 2:201-207 |
| ISSN: | 1618-565X 0938-7714 |
| DOI: | 10.1007/bf00216095 |
| Popis: | The clinical and immunohaeamatological effects of recombinant humen interleukin-2 (rhIL-2) administration were evaluated in normal dogs. Three groups of three dogs per group were administered rhIL-2 subcutaneously at a dose of 6 × 104 IU, 6 × 105 IU, or 6 × 106 IU/kg once daily for five consecutive days. Toxic clinical signs were limited primarily to diarrhoea, the severity of which, was dose dependent, with resolution within 7 days of the last rhIL-2 injection. Marked circulating eosinophilia occurred in dogs of the two highest dose groups and transient rise in blood lymphocyte numbers occurred in dogs given the highest dose of rhIL-2. The most significant immunological effects were elevated in vitro conA and pokeweed mitogen-stimulated lymphocyte blastogenic responsiveness in the highest dose group and dose-dependent elevation of antigen-specific antibody (IgG and IgM) production. Peak relative antibody production was markedly elevated, as compared to controls, in dogs administered 6 × 105 IU, 6 × 106 IU rhIL-2/kg. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink