Abschätzung der Tumorzellmasse bei der akuten lymphoblastischen Leukämie im Kindesalter: prognostische Bedeutung und praktische Anwendung*

Autor:	H. Riehm, Langermann Hj, M. Wulf, Günter Henze
Rok vydání:	1982
Předmět:	medicine.medical_specialty business.industry Lymphoblastic Leukemia Body weight medicine.disease Costal margin Gastroenterology Peripheral blood Leukemia medicine.anatomical_structure Internal medicine Pediatrics Perinatology and Child Health medicine Statistical analysis Risk factor business
Zdroj:	Klinische Pädiatrie. 194:209-213
ISSN:	1439-3824 0300-8630
Popis:	A retrospective statistical analysis of the acute lymphoblastic leukemia study BFM 70/76 revealed the prognosis being strongly dependent on the initial leukemia cell count/mm3 in the peripheral blood, and the enlargement of liver and spleen below the costal margin. Based on postmortem examinations reported in the literature a method was developed to estimate the tumor mass in these three compartments in an order of magnitude. The estimated blast cell mass related to the patient's body weight proved to be highly significant (p much less than 0.001). Simplification of the method led to the definition of a "risk factor" allowing the separation of patients into 3 groups with a distinctly different risk for relapse. In the current study BFM 81 the risk factor is used to stratify patients with respect to the individually needed therapeutic intensity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c34151fa48afd13523717a0ba362312a https://doi.org/10.1055/s-2008-1033807 Zobrazit plný text záznamu