| Autor: |
Irina Kadyrova, Sergey Yegorov, Baurzhan Negmetzhanov, Yevgeniya Kolesnikova, Svetlana Kolesnichenko, Ilya Korshukov, Dmitriy Vazenmiller, Yelena Stupina, Naylya Kabildina, Assem Ashimova, Aigul Raimbekova, Anar Turmukhambetova, Matthew S. Miller, Gonzalo Hortelano, Dmitriy Babenko |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.09.03.21262885 |
| Popis: |
BackgroundCOVID-19 exposure in Central Asia appears underestimated and SARS-CoV-2 seroprevalence data are urgently needed to inform ongoing vaccination efforts and other strategies to mitigate the regional pandemic. Here, we assessed the prevalence of anti-SARS-CoV-2 antibody-mediated immunity in a heterogeneous cohort of public university employees in Karaganda, Kazakhstan.MethodsAsymptomatic subjects (n=100) were recruited prior to their first COVID-19 vaccination. Questionnaires were administered to capture a range of demographic and clinical characteristics. Nasopharyngeal swabs were collected for SARS-CoV-2 RT-qPCR testing. Serological assays were performed to detect spike (S)-reactive IgG and IgA and to assess virus neutralization. Pre-pandemic samples were used to validate the assay positivity thresholds.ResultsAnti-S IgG and IgA seropositivity rates among SARS-CoV-2 PCR-negative participants (n=100) were 42% (95% CI [32.2-52.3]) and 59% (95% CI [48.8-69.0]), respectively, and 64% (95% CI [53.4-73.1]) of the cohort tested positive for at least one of the antibodies. Anti-S IgG titres correlated with virus neutralization activity, detectable in 49% of the tested subset with prior COVID-19 history. Serologically confirmed history of COVID-19 was associated with Kazakh ethnicity and self-reported history of respiratory illness since March 2020.ConclusionsSARS-CoV-2 exposure in this cohort is ∼15-fold higher compared to the reported all-time national and regional COVID-19 prevalence. Continuous serological surveillance is critical for understanding the COVID-19 transmission dynamics and should be nationally implemented to better inform the public health response in Central Asia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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