In vivoresponse to an implanted shape memory polyurethane foam in a porcine aneurysm model
| Autor: | Pooja Singhal, Matthew W. Miller, Fred J. Clubb, Duncan J. Maitland, Theresa W. Fossum, Thomas S. Wilson, Jennifer N. Rodriguez, Egemen Tuzun, Jonathan Hartman |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Neointima
Materials science Biocompatibility medicine.medical_treatment Metals and Alloys Biomedical Engineering Thrombogenicity medicine.disease Biomaterials chemistry.chemical_compound Aneurysm chemistry In vivo Ceramics and Composites medicine cardiovascular diseases Embolization Wound healing Polyurethane Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part A. 102:1231-1242 |
| ISSN: | 1549-3296 |
| Popis: | Cerebral aneurysms treated by traditional endovascular methods using platinum coils have a tendency to be unstable, either due to chronic inflammation, compaction of coils, or growth of the aneurysm. We propose to use alternate filling methods for the treatment of intracranial aneurysms using polyurethane-based shape memory polymer (SMP) foams. SMP polyurethane foams were surgically implanted in a porcine aneurysm model to determine biocompatibility, localized thrombogenicity, and their ability to serve as a stable filler material within an aneurysm. The degree of healing was evaluated via gross observation, histopathology, and low vacuum scanning electron microscopy imaging after 0, 30, and 90 days. Clotting was initiated within the SMP foam at time 0 ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text