MUCOADHESIVE AND MICROSPHERE: A SHORT REVIEW
| Autor: | Preeti Singh, Richa Tibrewal |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | International Journal of Medical and Biomedical Studies. 1 |
| ISSN: | 2589-8698 2589-868X |
| DOI: | 10.32553/ijmbs.v1i4.23 |
| Popis: | Microsphere constitutes an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Due to their short residence time, bioadhesive characteristics can be coupled to microsphere to develop mucoadhesive microsphere. Bioadhesion defined as state in which two materials, at least one of which is biological in nature, are held together for a prolonged time by the way of interfacial forces. Microsphere are the carrier around drug delivery system in which particle size in ranges from 1-1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. Mucoadhesive microsphere have advantages like efficient absorption and enhanced bioavailability of drugs due to high surface of volume ratio, a much more intimate contact with mucus layer, controlled and sustained release of drug from dosage form and specific targeting of drug to absorption site. This study aim to provide an overview of various aspects of mucoadhesive microsphere based on various polymers, method of preparation of mucoadhesive microsphere, method of evaluation and their applications in drug delivery system.Keywords: Mucoadhesive, microsphere, bioavailability. |
| Databáze: | OpenAIRE |
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