Host–guest complexes of docetaxel, an anti-cancer drug

Autor:	Pooja Guleria, Krishnamurthi Vyas, B. Selva Kumar, N. M. Sekhar, Palle V. R. Acharyulu, J. Moses Babu, T. Lakshmi Kumar, Peddy Vishweshwar, A. Sivalakshmidevi
Rok vydání:	2009
Předmět:	Hydrogen bond Stereochemistry Supramolecular chemistry General Chemistry Crystal structure Condensed Matter Physics Medicinal chemistry Inclusion compound Solvent chemistry.chemical_compound chemistry Docetaxel medicine Dimethylformamide Molecule Food Science medicine.drug
Zdroj:	Journal of Inclusion Phenomena and Macrocyclic Chemistry. 66:261-269
ISSN:	1573-1111 0923-0750
DOI:	10.1007/s10847-009-9606-x
Popis:	Host–guest complexes of Docetaxel 1, an anti-cancer drug have been isolated and crystal structures are described. Docetaxel crystallized in the 1:1 molar ratio with n-butanol, dimethylformamide (DMF) and acetonitrile (ACN) during crystallization from the respective solvents. In all the three complexes (1 · n-butanol, 1 · DMF and 1 · ACN), docetaxel formed a host framework through hydrogen bonds and the guest solvent molecules occupied the channels. The host is hydrogen bonded to the guest molecules through hydroxyl moieties. Interestingly, 1 · n-butanol, 1 · DMF and a literature 1 · CH3OH · H2O (1:1:1) host–guest complexes are isomorphs. Further, 1 · ACN complex unit cell parameters are similar (same space group) to the marketed docetaxel trihydrate polymorph (form A).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c31858c614e7835fa337ed4df6213864 https://doi.org/10.1007/s10847-009-9606-x Zobrazit plný text záznamu Full text from SpringerLink