Autor: |
Alison J. Moskowitz, Oliver Sartor, Charles L. Bennett, Alain H. Rook, Thomas Coyne, Gloria von Geldern, Craig H. Moskowitz, Ellen J. Kim, Alison W. Loren, Dennis W. Raisch, Scott D. Newsome, LeAnn B. Norris, Donald E. Tsai, Nina D. Wagner-Johnston, Kenneth R. Carson, Daniel J. Landsburg, P. Brandon Bookstaver, Pankaj Jalan |
Rok vydání: |
2014 |
Předmět: |
|
Zdroj: |
Cancer. 120:2464-2471 |
ISSN: |
0008-543X |
Popis: |
Purpose Brentuxiumab vedotin (BV) is an anti-CD30 monoclonal antibody-drug conjugate approved in 2011 for treating anaplastic large cell and Hodgkin lymphomas. The product label indicates that three BV-treated patients developed progressive multifocal leukoencephalopathy (PML), a frequently fatal JC-virus induced central nervous system infection. Prior immunosuppressive therapy and compromised immune systems were postulated risk factors. We report 5 patients who developed BV-associated PML, including two immunocompetent patients. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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