Pancreatic Stone Protein
| Autor: | Lucas Boeck, Rolf Graf, Nehal Thakkar, Dimitri A. Raptis, Michael Tamm, Janko Rakic, Daiana Stolz, Philippe Eggimann, Nicholas A. Smyrnios, Hans Pargger, Martin Siegemund |
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| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Intensive care medicine Survival rate Critically ill business.industry Ventilator-associated pneumonia 030208 emergency & critical care medicine Retrospective cohort study bacterial infections and mycoses medicine.disease eye diseases respiratory tract diseases 3. Good health Pneumonia medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) Pancreatic stone protein Cardiology and Cardiovascular Medicine Pancreas business |
| Zdroj: | Chest. 140:925-932 |
| ISSN: | 0012-3692 |
| Popis: | Background Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of nosocomial pneumonia remain a global burden. Currently, physicians rely on their experience to discriminate patients with good and poor outcome. However, standardized prognostic measures might guide medical decisions in the future. Pancreatic stone protein (PSP)/regenerating protein (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill patients is unknown. The aim of this pilot study was to evaluate PSP/reg in VAP. Methods One hundred one patients with clinically diagnosed VAP were assessed. PSP/reg was retrospectively analyzed using deep-frozen serum samples from VAP onset up to day 7. The main end point was death within 28 days after VAP onset. Results Serum PSP/reg was associated with the sequential organ failure assessment score from VAP onset (Spearman rank correlation coefficient 0.49 P Conclusions Serum PSP/reg is a biomarker related to organ failure and outcome in patients with VAP. Trial registry ISRCTN.org; No.: ISRCTN61015974; URL: www.isrctn.org. |
| Databáze: | OpenAIRE |
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