Combined D3 Receptor/Iron-Deficient Mouse Model
| Autor: | D. Liebetanz, F. Klinker |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Period (gene) Persistent pain Iron deficiency medicine.disease Phenotype 03 medical and health sciences 0302 clinical medicine Animal model Endocrinology Dopamine receptor D3 Internal medicine mental disorders medicine Iron deficient Restless legs syndrome Psychology 030217 neurology & neurosurgery 030304 developmental biology |
| Popis: | In addition to genetic factors, several secondary causes of restless legs syndrome (RLS) are known. Nevertheless, the exact pathomechanism eliciting RLS symptoms remains elusive, supporting the need for an animal model of RLS. As one genetically determined factor, reduced dopamine D3 receptor (D3R) function has been proposed. Iron deficiency is the most widely accepted secondary factor for the development of RLS. Mice lacking the D3R and made iron deficient exhibit increased locomotion before the resting period and enhanced responses to both acute and persistent pain stimuli. The behavioral changes observed in these animals are commensurate with what one would expect as the RLS phenotype in mice and underline the value of the combined D3R and iron-deficient mouse model of RLS. The assessment of therapeutic effects and the characterization of sleep changes in this model could further prove the validity of the presented model. |
| Databáze: | OpenAIRE |
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