IMPROVING EFFICIENCY OF ANTIOXIDANT AND CYTOPROTECTIVE THERAPY IN PATIENTS WITH NSAID-GASTROPATHY AND CONCOMITANT ISCHEMIC HEART DISEASE
| Autor: | V. V. Parkhomenko, I. M. Skrypnyk, A. F. Hopko |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gastric mucosal barrier
medicine.medical_specialty Antioxidant biology business.industry medicine.medical_treatment Disease Helicobacter pylori biology.organism_classification medicine.disease_cause Gastroenterology Catalase Concomitant Internal medicine biology.protein medicine Ischemic heart business Oxidative stress |
| Zdroj: | Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії. 20:111-114 |
| ISSN: | 2077-1126 2077-1096 |
| DOI: | 10.31718/2077-1096.20.1.111 |
| Popis: | Introduction. Non-steroidal anti-inflammatory drugs (NSAID) are remaining to be the gold standard of antiplatelet therapy for ischemic heart disease, but at the same time NSAID therapy is associated with a number of side effects and risks, among which the leading place is ranked by gastropathy. The aim of this study was to explore the ways in improving the effectiveness of the integrated therapy modification for patients who had gastropathy not associated with Helicobacter Pylori, and concomitant ischemic heart disease, by including Artemisia Argyi leaf extract. Materials and methods. The study involved 82 patients, who, depending on prescribed therapeutic schemes were divided into two groups: I (n=44) group took proton pump inhibitors in standard doses (standard therapy) and II group (n=38), who, in addition to the standard mode of the therapy took Artemisia Argyi leaf extract. The condition of gastric mucosal barrier was assessed by the serum content of N-acetylneuraminic acid and fucoproteins; oxidative stress activity was evaluated by serum TBA concentration and catalase activity. Results. The patients who took Artemisiae Argyi extract and the proton pump inhibitor therapy have demonstrated the increase in mucosal barrier resistance of the gastroduodenal area that was confirmed by reducing of N-acetylneuraminic acid in serum in 1.2 times (p |
| Databáze: | OpenAIRE |
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