Isolation and biological evaluation of roseofungin and its cyclodextrin inclusion complexes
| Autor: | R.A. Khannanov, R. I. Jalmakhanbetova, Business, Nur-Sultan, Kazakhstan, Ahmed M. Metwaly, Zh. B. Iskakova, 'Biolife\\' Ltd, Stepnogorsk, Kazakhstan, Ibrahim H. Eissa, T.M. Seilkhanov, Ye.M. Suleimen, G.G. Sissengaliyeva, D.S. Balpanov |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Bulletin of the Karaganda University. "Chemistry" series. 100:35-44 |
| ISSN: | 2663-4872 2518-718X |
| DOI: | 10.31489/2020ch4/35-44 |
| Popis: | Roseofungin belongs to polyene antibiotics which is more active and less toxic comparing other polyenes of this group. Roseofungin was isolated from Actinomyces roseoflavus var. Roseofungini using different chro-matographic techniques and for the first time, the complexation of roseofungin with α-, β- and γ-cyclodextrin derivatives was performed. The binding patterns of the resulted complexes were studied in silico using mo-lecular docking techniques. The best binding mode was for roseofungin against γ-CD with an affinity value of ˗42.98 kcal/mol. The proposed binding mode of roseofungin against α-CD showed unusual interaction with an affinity value of ˗41.80 kcal/mol. Also, roseofungin bonded to β-CD with a binding affinity value of ˗35.03 kcal/mol. The antiradical and cytotoxic activities of roseofungin and its obtained α-, β- and γ-cyclo-dextrin complexes were determined. The antiradical activity was performed using butylhydroxyanisole as a reference, while the cytotoxic activity was determined using Artemia salina crustaceans. As a result of the biological activity study, it was found that roseofungin and some of its complexes have weak antiradical activities. |
| Databáze: | OpenAIRE |
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