Total synthesis of octalactin A via ring-closing metathesis reaction

Autor:	Youngmee Jeong, Nagaaki Sato, Keith R. Buszek
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Antitumor activity chemistry.chemical_compound Ring-closing metathesis Natural product Stereochemistry Chemistry Organic Chemistry Drug Discovery Total synthesis Metathesis Biochemistry Lactone
Zdroj:	Tetrahedron Letters. 43:181-184
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)02078-0
Popis:	A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c2ed3fe64e9376e413d07616ede5c187 https://doi.org/10.1016/s0040-4039(01)02078-0 Zobrazit plný text záznamu Full Text from ScienceDirect