Green Tea Polyphenol Epigallocatechin-3-O-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells
| Autor: | Seung-Jae Lee, Hyun Woo Kang, Sun Jin Hur, Seung Yuan Lee |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Lipopolysaccharide
biology Chemistry food and beverages Inflammation Pharmacology complex mixtures Nitric oxide Nitric oxide synthase chemistry.chemical_compound Biochemistry Downregulation and upregulation Polyphenol medicine biology.protein Macrophage heterocyclic compounds Secretion sense organs medicine.symptom |
| Zdroj: | Journal of Food and Nutrition Research. 2:425-428 |
| ISSN: | 2333-1119 |
| Popis: | Epigallocatechin-3-O-gallate (EGCG), the major polyphenol found in green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) is known to be closely correlated with the pathology of a variety of diseases and inflammations. In this study, we investigated the inhibitory effect of EGCG on NO production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophage RAW264.7 cells. Besides a decrease in NO secretion, protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) also decreased in LPS-stimulated RAW264.7 macrophage cells treated with EGCG. These results suggest that EGCG possesses a potent anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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