Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes
| Autor: | Enrique España-Gregori, Noemi Burguera-Giménez, Manuel Rodríguez-Vallejo, Gowtham Jonna, Santiago García-Lázaro, Roberto Gallego-Pinazo, Neus Burguera-Giménez |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures medicine.diagnostic_test business.industry Visual impairment eye diseases Geographic atrophy 03 medical and health sciences Ophthalmology 0302 clinical medicine Optical coherence tomography Visual function Fixation (visual) 030221 ophthalmology & optometry medicine Spatial frequency medicine.symptom business Microperimetry 030217 neurology & neurosurgery |
| Zdroj: | Clinical Ophthalmology. 14:1533-1545 |
| ISSN: | 1177-5483 |
| Popis: | Purpose To comprehensively evaluate visual function in eyes with geographic atrophy (GA) as compared to normal eyes. Patients and Methods Sixty-three eyes from 63 patients ≥50 years old were recruited for this observational study; 31 were identified as normal macular health eyes and 32 with GA. Visual function was tested with best corrected visual acuity (BCVA), low luminance visual acuity (LLVA), low luminance deficit (LLD), reading speed, macular integrity microperimetry, fixation stability, and contrast sensitivity function (CSF). Anatomic function was evaluated with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Quality of life and vision were assessed with the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Results Visual function and quality of life are reduced in patients with GA. Moderate and strong correlations in the GA group were found between maximum reading speed (r = 0.787) (p˂0.01), CS spatial frequency 3 cpd (r = 0.441) (p˂0.05), CS spatial frequency 6 cpd (r = 0.524) (p˂0.01), fixation P1 (r = 0.379) (p˂0.05), macular sensitivity (r = 0.484) (p˂0.05) and atrophic area (r = -0.689) (p˂0.01), and the VFQ-25 composite score. Conclusion The decreased visual function is reflected in a poor quality of life in patients with GA. Reading speed, contrast sensitivity, fixation, and macular sensitivity are strongly associated with vision-related quality of life. The results suggest the importance of the reading letter size in patients with GA. Microperimetry and reading speed are useful tools to better assess visual impairment in patients with GA. |
| Databáze: | OpenAIRE |
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