Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model

Autor:	Yi Jen Chen, Yung Nan Tsai, Chiao Po Hsu, Shuen Hsin Liu, Shih Lin Chang, Eric Chong, Shuo Ju Chiang, Man Cai Fong, Ya Wen Hsiao, Chuen Wang Chiou, Rahul Singhal, Shih Ann Chen, Yao Chang Chen
Rok vydání:	2016
Předmět:	0301 basic medicine medicine.medical_specialty Ejection fraction biology business.industry Histology Atrial fibrillation 030204 cardiovascular system & hematology Pharmacology biology.organism_classification medicine.disease Placebo 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Enos Physiology (medical) Internal medicine Heart failure Rhodiola medicine Cardiology Cardiology and Cardiovascular Medicine business Protein kinase B
Zdroj:	Journal of Cardiovascular Electrophysiology. 27:1093-1101
ISSN:	1045-3873
Popis:	INTRODUCTION Rhodiola, a popular plant in Tibet, has been proven to decrease arrhythmia. The aim of this study was to elucidate the molecular mechanism and electrophysiological properties of rhodiola in the suppression of atrial fibrillation. METHODS This study consisted of 3 groups as follows: Group 1: normal control rabbits (n = 5); Group 2: rabbits with heart failure (HF) created by coronary ligation and who received 2 weeks of water orally as a placebo (n = 5); and Group 3: rabbits with HF who received 2 weeks of a rhodiola 270 mg/kg/day treatment orally (n = 5). The monophasic action potential, histology, and real-time polymerase chain reaction (RT-PCR) analysis of ionic channels and PI3K/AKT/eNOS were examined. RESULTS Compared with the HF group, attenuated atrial fibrosis (35.4 ± 17.4% vs. 16.9 ± 8.4%, P = 0.05) and improved left ventricular (LV) ejection fraction (51.6 ± 3.4% vs. 68.0 ± 0.5%, P = 0.001) were observed in the rhodiola group. The rhodiola group had a shorter ERP (85.3 ± 6.8 vs. 94.3 ± 1.2, P = 0.002), APD90 (89.3 ± 1.5 vs. 112.7 ± 0.7, P < 0.001) in the left atrium (LA), and decreased AF inducibility (0.90 ± 0.04 vs. 0.42 ± 0.04, P < 0.001) compared with the HF group. The mRNA expressions of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, and SERCA2a in the HF LA were up-regulated after rhodiola treatment. The rhodiola-treated HF LA demonstrated higher mRNA expression of PI3K-AKT compared with the HF group. CONCLUSIONS Rhodiola reversed LA electrical remodeling, attenuated atrial fibrosis and suppressed AF in rabbits with HF. The beneficial electrophysiological effect of rhodiola may be related to upregulation of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, SERCA2a, and activation of PI3K/AKT signaling.
Databáze:	OpenAIRE
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