Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

Autor:	Ernest Hamel, Philip Proteau, Andrei V. Blokhin, Doris L. Slate, William H. Gerwick, Dale G. Nagle
Rok vydání:	1994
Předmět:	Cyanobacteria Natural product biology Organic Chemistry Brine shrimp Biological activity biology.organism_classification Toxicology chemistry.chemical_compound Tubulin chemistry Biochemistry biology.protein Colchicine Antimitotic Agent Lyngbya majuscula
Zdroj:	The Journal of Organic Chemistry. 59:1243-1245
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo00085a006
Popis:	Bioassay-guided fractionation of the organic extract of a Curacao collection of Lyngbya majuscula led to the isolation of a new lipid, curacin A, with exceptional brine shrimp toxic and antiproliferative activities. Its unique thiazoline-containing structure has been deduced from spectroscopic information. Pure curacin A is an antimitotic agent (IC 50 values in three cell lines ranging from 7 to 200 nM) that inhibits microtubule assembly and the binding of colchicine to tubulin
Databáze:	OpenAIRE
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