Collective Total Synthesis of β-Carboline-Type Monoterpenoid Indole Alkaloid Glycosides
| Autor: | Hayato Ishikawa, Daiki Hiruma, Jukiya Sakamoto, Mariko Kitajima |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Synlett. |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | The collective and efficient asymmetric total syntheses of five β-carboline-type monoterpenoid indole alkaloid glycosides were achieved in fewer than thirteen steps. A Pictet–Spengler reaction with α-cyanotryptamine followed by the removal of the cyano group and autoxidation (aromatization) efficiently constructed the β-carboline motif. In addition, bioinspired reactions were developed to provide different alkaloid skeletons. |
| Databáze: | OpenAIRE |
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