Interaction of pyracetam with specific3H-imipramine binding sites and GABA-benzodiazepine receptor complex of brain membranes

Autor:	N. D. Danchev, K. K. Chakhbra, A. V. Val'dman, D. Yu. Rusakov, K. M. Malin, V. V. Rozhanets
Rok vydání:	1986
Předmět:	Benzodiazepine Receptor complex medicine.drug_class Endogeny General Medicine Pharmacology Biology Imipramine Anxiolytic General Biochemistry Genetics and Molecular Biology In vivo medicine Binding site Receptor medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 101:51-53
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00836073
Popis:	This paper studies the effect of pyracetam on parameters of specific binding of tritium-imipramine and GABA-activated binding of tritium-flunitrazepam with rat brain membranes. The experimental method is described and it is shown that pyracetam and mebicar in experiments in vivo on normal animals can exert their anxiolytic action without the participation of bensodiazepine receptors. Either the interaction of pyracetam and mebicar with benzodiazeprine receptors has a different interpretation than competition of these compounds with specific binding sites of tritium-flunitrazepam, or in experiments on normal animals in vivo GABA-benzodiazepine receptor complex does not accept pyracetam and mebicar, for it contains endogenous inhibitors of GABA-modulating action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c2c2c1c804257f8008772c816377e264 https://doi.org/10.1007/bf00836073 Zobrazit plný text záznamu Full text from SpringerLink