Copper (cat) and phenylboronic acid mediated deformylative C-N coupling of isoindolinone-3-ols with formamides provide C(3) aminoisoindolinones
| Autor: | A Veera Bhadra Rao, J Prabhakaran, H. Surya Prakash Rao, Silambarasan Kanniyappan |
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| Rok vydání: | 2018 |
| Předmět: |
Formamide
chemistry.chemical_classification Primary (chemistry) 010405 organic chemistry Iodide chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Copper 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Amine gas treating Phenylboronic acid Formamides |
| Zdroj: | Journal of Chemical Sciences. 130 |
| ISSN: | 0973-7103 0974-3626 |
| DOI: | 10.1007/s12039-018-1474-8 |
| Popis: | Copper(I) iodide efficiently catalyzes deformylative C-N coupling of formamides and isoindolinone-3-ols to provide C(3) primary/secondary amine substituted isoindolinones. The transformation requires a stoichiometric amount of phenylboronic acid as a co-reactant. In the reaction, formamides act as the synthetic equivalent of primary/secondary amines. The method is amenable for the synthesis of a combinatorial library of medicinally relevant C(3) amino substituted isoindolinones. Copper(I) iodide efficiently catalyzes deformylative C-N coupling of formamides and isoindolinone-3-ols in presence of stoichiometric amount of phenylboronic acid (co-reactant) to provide C(3) primary/secondary amine substituted isoindolinones. Here, formamides act as synthetic equivalents of primary/secondary amines. Herein we report synthesis of a combinatorial library of medicinally relevant C(3) amino substituted isoindolinones. |
| Databáze: | OpenAIRE |
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