Mitochondrial genome deletions in the brain and their role in neurodegenerative diseases

Autor: Carl R. Merril, Steve Zullo
Rok vydání: 1995
Předmět:
Zdroj: International Review of Psychiatry. 7:385-398
ISSN: 1369-1627
0954-0261
DOI: 10.3109/09540269509022989
Popis: SummaryMany of the acute and chronic diseases affecting the central nervous system (CNS) are still of unknown etiology. Given that brain cells are the most aerobic and metabolically active cells in the body, deficits in aerobic energy metabolism may play an important role in many of these diseases. Over the past decade numerous diseases affecting highly active metabolic tissues including the brain and skeletal musculature have been shown to be associated with alterations in the mitochondria, the subcellular organelle responsible for aerobic energy metabolism. In addition, a number of maternally inherited diseases have been linked to mutations in the circular, 16,569 nucleotide pair mitochondrial genome. Mendelian inherited genetic variations and diseases have also been found to affect the mitochondrial function, structure, and genome in certain tissues. Specific regions of the brain appear to be more prone to the occurrence of mitochondrial DNA (mtDNA) deletion mutations. For example, mtDNA extracted from...
Databáze: OpenAIRE
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