A chiral phosphine–olefin ligand derived from l-hydroxyproline and its use in the rhodium-catalyzed asymmetric 1,4-addition

Autor:	Tamio Hayashi, Yixin Lu, Vasudeva Rao Gandi
Rok vydání:	2015
Předmět:	Olefin fiber Chemistry Ligand Stereochemistry Organic Chemistry Chiral ligand chemistry.chemical_element Medicinal chemistry Catalysis Rhodium Inorganic Chemistry chemistry.chemical_compound Reagent L-Hydroxyproline Physical and Theoretical Chemistry Phosphine
Zdroj:	Tetrahedron: Asymmetry. 26:679-682
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2015.05.004
Popis:	A new chiral phosphine–olefin ligand (S)-1 has been designed and synthesized from l-hydroxyproline via a short reaction sequence. It was examined for its efficiency in the rhodium-catalyzed asymmetric addition of arylboronic acids and a phenylzinc reagent to cyclic α,β-unsaturated ketones, giving 1,4-addition products with high enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c2b27f144725457989e87ca37b96627a https://doi.org/10.1016/j.tetasy.2015.05.004 Zobrazit plný text záznamu Full Text from ScienceDirect