| Autor: |
Dippe, Martin, Bauer, Anne-Katrin, Porzel, Andrea, Funke, Evelyn, Müller, Anna O., Schmidt, Jürgen, Beier, Maria, Wessjohann, Ludger A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| DOI: |
10.23689/fidgeo-4860 |
| Popis: |
We present a bioorthogonal method for the ligation of coenzyme A (CoA) with cinnamic acids. The reaction, which is the initial step in the biosynthesis of a multitude of bioactive secondary metabolites, is catalyzed by a promiscuous plant ligase and yields CoA conjugates with different functionalization in high purity and without formation of by-products. Its applicability in biosynthetic cascades is shown for the direct transformation of cinnamic acids into natural benzaldehydes (like vanillin) or artificial derivatives (e. g. ethylvanillin). image |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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