Developmental regulation of subtype-specific motor neuron excitability
| Autor: | Angeles B. Ribera, Rosa L. Moreno |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
education.field_of_study
biology Spinal neuron General Neuroscience Sodium channel Population Motor neuron biology.organism_classification Spinal cord Embryonic stem cell General Biochemistry Genetics and Molecular Biology Electrophysiology medicine.anatomical_structure nervous system History and Philosophy of Science medicine education Zebrafish Neuroscience |
| Zdroj: | Annals of the New York Academy of Sciences. 1198:201-207 |
| ISSN: | 0077-8923 |
| Popis: | At early embryonic stages, zebrafish spinal neuron subtypes can be distinguished and accessed for physiological studies. This provides the opportunity to determine electrophysiological properties of different spinal motor neuron subtypes. Such differences have the potential to then regulate, in a subtype-specific manner, activity-dependent developmental events such as axonal outgrowth and pathfinding. The zebrafish spinal cord contains a population of early born neurons. Our recent work has revealed that primary motor neuron (PMN) subtypes in the zebrafish spinal cord differ with respect to electrical properties during early important periods when PMNs extend axons to their specific targets. Here, we review recent findings regarding the development of electrical properties in PMN subtypes. Moreover, we consider the possibility that electrical activity in PMNs may play a cell nonautonomous role and thus influence the development of later developing motor neurons. Further, we discuss findings that support a role for a specific sodium channel isoform, Nav1.6, expressed by specific subtypes of spinal neurons in activity-dependent processes that impact axonal outgrowth and pathfinding. |
| Databáze: | OpenAIRE |
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