Determination of the 'Amino Acid Conflicts' and amino acid substitutions in primary structures of 41 human proteins by the proteomic technologies

Autor:	Marina V. Serebryakova, L. I. Kovalyov, Alexander I. Archakov, S. S. Shishkin, Alexander A. Makarov, M. A. Kovalyova, Lidia S. Eryomina, M. V. Burakova, I. Yu. Toropygin
Rok vydání:	2008
Předmět:	Genetics Gene isoform chemistry.chemical_classification Clinical Biochemistry Alternative splicing Biology Proteomics Biochemistry Amino acid medicine.anatomical_structure Antigen chemistry Prostate medicine Molecular Medicine Myocyte Bioorganic chemistry
Zdroj:	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2:325-334
ISSN:	1990-7516 1990-7508
DOI:	10.1134/s199075080804001x
Popis:	Proteomic studies of some human tissues and organs (skeletal muscles, myometrium, motor zone of the brain, prostate), and also cultivated myoblasts revealed 41 proteins, in which the presence of certain variants of amino acids (“conflicts”) was recognized at several “conflict” positions. Among the 93 registered “amino acid conflicts”, seven cases represented the results of the protein polymorphisms caused by corresponding substitution of individual amino acid. Proteomic analysis of prostate proteins revealed two isoforms of a prostate-specific antigen, formed due to alternative splicing. Thus, our results have shown that employment of the proteomic technologies may characterize various types of biochemical polymorphism in many human proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c299227ef9f414f68368f3689f77d6f4 https://doi.org/10.1134/s199075080804001x Zobrazit plný text záznamu Full text from SpringerLink