Preparation of 227Ac/223Ra by neutron irradiation of 226Ra
| Autor: | Ekaterina Kukleva, Ján Kozempel, Petra Mičolová, Martin Vlk, D. Vopálka |
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| Rok vydání: | 2014 |
| Předmět: |
Health
Toxicology and Mutagenesis Targeted radionuclide therapy Radiochemistry Public Health Environmental and Occupational Health chemistry.chemical_element Pollution Analytical Chemistry Radium Cross section (physics) Actinium Nuclear Energy and Engineering chemistry Yield (chemistry) Radiology Nuclear Medicine and imaging Nuclide Neutron irradiation Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 304:263-266 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-014-3432-3 |
| Popis: | Radium-223 is a prospective alpha-emitter for targeted radionuclide therapy. Although 223Ra is formed naturally by the decay of 235U, for practical reasons its preparation involves neutron irradiation of 226Ra. The β− decay of the 227Ra (T ½ = 43 min) produced via 226Ra(n,γ)227Ra reaction leads to 227Ac, a mother nuclide of 227Th and subsequently 223Ra. Radium target material is generally available in multigram quantities from historical stock. The main aim of this study was to experimentally as well as theoretically evaluate and verify the available literature data on production of 227Ac/223Ra. According to the data obtained from the γ-spectra, the approximate yield values were determined and effective cross section value for the 227Ac production was calculated to 14 ± 4 b. |
| Databáze: | OpenAIRE |
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