Assessment of acaricidal activity of nanoscale ZnO encapsulated piperine formulation against Rhipicephalus microplus
| Autor: | Sreedevi Bollini, Prasad Tollamadugu Naga Venkata Krishna Vara, Snigdha Kancharana, Rayulu Vukka Chengalva, Srinivasa Rao Kothapalli, Muralidhar Yegireddy |
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| Rok vydání: | 2020 |
| Předmět: |
Tick infestation
biology Acaricide chemistry.chemical_element 02 engineering and technology Zinc 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification 01 natural sciences Fourier transform infrared spectra 0104 chemical sciences Electronic Optical and Magnetic Materials chemistry.chemical_compound Deltamethrin chemistry Piperine medicine Rhipicephalus microplus Electrical and Electronic Engineering 0210 nano-technology IC50 Biotechnology Nuclear chemistry |
| Zdroj: | IET Nanobiotechnology. 14:722-731 |
| ISSN: | 1751-875X 1751-8741 |
| DOI: | 10.1049/iet-nbt.2020.0159 |
| Popis: | This study aims to synthesise and evaluate the acaricidal activity of nanoscale zinc oxide piperine formulation (NZPF) against Rhipicephalus microplus ticks. NZPF was prepared by using zinc oxide nanoparticles (ZnONPs) and piperine by employing encapsulation technique; characterised by UV spectroscopy, Fourier transformed infrared analysis, X-ray diffraction, dynamic light scattering, zetapotential and scanning electron microscopy. Acaricidal activity of the NZPF on R. microplus was evaluated using larval packet test (LPT) and adult immersion test (AIT). LPT against R. microplus larvae showed an LC50 at 1 mg/l for NZPF followed by 2 and 3 mg/l for ZnONPs and piperine, respectively. AIT against R. microplus showed an LC50 at concentration of 3 mg/l for NZPF followed by 6 mg/l for ZnONPs and 7 mg/l for piperine. In both LPT and AIT, LC50 values of ZnONPs and NZPF were significantly lower compared to deltamethrin. NZPF showed significant ovulation inhibitory activity with lower IC50 and IC99 values compared to ZnONPs and piperine. NZPF has been proved to be the better alternative to routine chemical acaricides for control of tick infestation of cattle in the wake of acaricidal resistance, but safety issues need to be addressed before clinical application. |
| Databáze: | OpenAIRE |
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