MIF-1 AND REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL SYSTEM IN DEPRESSION

Autor:	R.H. Ehrensing, A.J. Kastin
Rok vydání:	1982
Předmět:	medicine.medical_specialty Imipramine chemistry.chemical_compound Endocrinology chemistry Hypothalamus Internal medicine medicine Endocrine disturbance Opiate Neurotransmitter Psychology Depression (differential diagnoses) Serum cortisol medicine.drug
DOI:	10.1016/b978-0-08-027987-9.50035-4
Popis:	A significant mean decrease in the concentration of serum cortisol drawn at 4 PM was observed in a group of five depressed patients after they received MIF-1 (prolyl-leucyl-glycinamide) 60 mg p.o. at 8 AM for seven days as compared to the 4 PM value before administration of the peptide. A similar but nonsignificant trend was seen with MIF-1 10 mg per day. These results are compatible with the known relationships among ACTH, opiates and MIF-1. It is possible that MIF-1 may reduce the hyperactivity of the hypothalamic-pituitary adrenal axis in depression by blocking an as yet undetermined opiate peptide or neurotransmitter responsible both for the dysfunction of affect as well as the endocrine disturbance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c288efba0e4865ca785d66dda372aaab https://doi.org/10.1016/b978-0-08-027987-9.50035-4 Zobrazit plný text záznamu