Genomic Analysis of Citrobacter Portucalensis Sb-2 Identifies a Phage Predation Driven Metalloid Resistance

Autor: Zhenchen Xie, Yanshuang Yu, Jinxuan Liang, Renwei Feng, JiGang Yang, Qiue Yang, Yong-Guan Zhu, Martin Herzberg, Christopher Rensing, YuanPing Li, Hend A. Alwathnani
Rok vydání: 2021
Předmět:
DOI: 10.21203/rs.3.rs-470342/v1
Popis: Bacterial adaptation to extreme environments is often mediated by horizontal gene transfer (HGT). At the same time, phage mediated HGT for conferring bacterial arsenite and antimonite resistance has not been documented before. In this study, a highly arsenite and antimonite resistant bacterium, C. portucalensis strain Sb-2, was isolated and subsequent genome analysis showed that putative arsenite and antimonite resistance determinants were flanked or embedded by prophages. We predict these phage-mediated resistances play a significant role in maintaining genetic diversity within the genus of Citrobacter and are responsible for endowing the corresponding resistances to C. portucalensis strain Sb-2.
Databáze: OpenAIRE