Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis

Autor:	Masayuki Chida, Satoru Kobayashi, Yoshimasa Nakazato, Sumiko Maeda, Yoko Karube, Takashi Inoue
Rok vydání:	2018
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Multivariate analysis biology business.industry Pulmonary adenocarcinoma General Medicine medicine.disease Primary tumor Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Histone 030220 oncology & carcinogenesis Cancer cell biology.protein Immunohistochemistry Phosphorylation Medicine business Mitosis
Zdroj:	Pathology International. 68:159-166
ISSN:	1320-5463
DOI:	10.1111/pin.12635
Popis:	Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis-specific marker. We evaluated the correlation between pHH3-stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined. Cases with a cancer-cell index ≥1000 showed worse recurrence-free survival as compared to those with a value
Databáze:	OpenAIRE
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