Leukocytolysis and phagocytosis under hyperosmotic conditions

Autor:	L. A. Apollonova, A. A. Belopol'skii, E. K. Nazarova, M. P. Vavilov
Rok vydání:	1992
Předmět:	Osmotic concentration Phagocytosis Drug allergy General Medicine Osmosis medicine.disease General Biochemistry Genetics and Molecular Biology Strong solutions chemistry.chemical_compound Biochemistry chemistry Glycerol medicine Tonicity
Zdroj:	Bulletin of Experimental Biology and Medicine. 114:1681-1683
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00837671
Popis:	PAN and leukocytolysis were measured in dog blood placed in hypo- and hypertonic solutions of glycerin and glucose (1:10). It was found that leukocytolytic activity of the substances depends on equimolar concentrations of nonelectrolytes. It is more pronounced in hypo- than in hypertonic conditions. Glycerin is 3-5-times more active than glucose. In concentrations 2.0 M for glycerin and 0.5 M for glucose leukocytolysis is less active. Mononuclears are more resistant than neutrophils in strong solutions. PAN increased by 11-16% in hypotonic solutions. Strong glycerin solutions reduce PAN less than glucose which stimulates the digestive activity. The results can be of use in specific leukolysis tests to diagnose drug allergy.
Databáze:	OpenAIRE
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