Thymic Abnormalities in Fetuses Aborted From Human Immunodeficiency Virus Type 1 Seropositive Women

Autor:	N. Mulliez, Jean-François Bach, Roger Henrion, Claude Griscelli, Martine Papiernik, Yves Brossard, Christian Bréchot, Alain Goudeau, Francis Barin, Rosemay Vazeux, Joelle Roume
Rok vydání:	1992
Předmět:	Fetus Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Immunosuppression In situ hybridization Immunofluorescence Virus Immature Lymphocyte Lymphatic system HIV Antigens Pediatrics Perinatology and Child Health Immunology Medicine business
Zdroj:	Pediatrics. 89:297-301
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.89.2.297
Popis:	Pathological abnormalities of the thymus were found in 3 of 37 fetuses aborted from human immunodeficiency virus (HIV)-infected mothers. These lesions were located predominantly in the thymic cortex, which contains mostly immature lymphocytes. Areas of focal lymphocyte depletion were infiltrated with CD4+ macrophages and were associated with abnormalities of the epithelial stromal network. No evidence of extensive HIV infection in any of the 37 thymuses was detected by either immunofluorescence or in situ hybridization techniques, although rare cells that expressed HIV antigens were found in 3 fetuses. Although less extensive, this thymic fetopathy was similar to that described in postnatal acquired immunodeficiency syndrome thymuses, strongly suggesting that the lesions were related to HIV infection. Thymic fetopathy might represent the initial injury to the lymphoid system in HIV-infected infants in whom early and severe immunosuppression develops.
Databáze:	OpenAIRE
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