| Autor: | Toshikiro Kimura, Ken Ichi Ogawara, Kazuki Nakayama, Hisae Matsuura, Masahide Asai, Kazutaka Higaki |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Disposition kinetics business.industry Organic Chemistry Pharmacology toxicology Pharmaceutical Science Systemic absorption Disposition Pharmacokinetics Molecular Medicine Medicine Distribution (pharmacology) Pharmacology (medical) Tissue distribution Compartment (pharmacokinetics) business Biotechnology |
| Zdroj: | Pharmaceutical Research. 16:302-308 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1018844928818 |
| Popis: | Purpose. The objectives of dermal application of drugs are not only systemic therapeutics, but also local ones. We would expect its intradermal kinetics to be dependent on its therapeutic purpose. To develop more efficient drugs for local or systemic therapeutics, it will be important to estimate quantitatively the intradermal disposition of drugs applied topically. We tried, therefore, to develop the compartment model to describe the intradermal disposition kinetics after topical application of drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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