Asymmetric Synthesis of P-Stereogenic Secondary Phosphine ­Oxides (SPOs)

Autor:	David S. Glueck
Rok vydání:	2021
Předmět:	Chiral auxiliary Organic Chemistry Resolution (electron density) Enantioselective synthesis Diastereomer Combinatorial chemistry Catalysis Kinetic resolution Stereocenter Metal chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Phosphine
Zdroj:	Synthesis. 54:271-280
ISSN:	1437-210X 0039-7881
DOI:	10.1055/a-1582-0169
Popis:	P-Stereogenic secondary phosphine oxides [SPOs, RR′P(O)H], valuable ligands for metal complexes in asymmetric catalysis, are also building blocks for other chiral phosphorus derivatives. This short review summarizes methods used for asymmetric synthesis of P-stereogenic SPOs.1 Introduction2 Configurational Stability of P-Stereogenic SPOs3 Classical Resolution, HPLC Separation, and Dynamic Resolution4 Synthesis via Chiral Auxiliaries5 Kinetic Resolution6 Conclusions and Outlook
Databáze:	OpenAIRE
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