| Autor: |
Alexander Cobb, Qi Lin, Hao Lan, Kenneth Shankland, Rebecca Musgrave, Peter Horton, Carsten Baldauf, Hans-Jorg Hofmann, Craig Butts, Manuel Mueller, Chunmiao Ma |
| Rok vydání: |
2023 |
| DOI: |
10.26434/chemrxiv-2023-ks4t3 |
| Popis: |
We report the first structures of an unusual 13/11-helix (alternating i,i+1 {NH--O=C} and i,i+3 {C=O--H—N} H-bonds) formed by a heteromeric 1:1 se-quence of alpha- and delta-amino acids, using both XRD and NMR. Whilst intramolecular hydrogen bonds (IMHBs) are the clear driver of helix formation, we also observe an apolar interaction between the ethyl residue of one delta-amino acid and the cyclohexyl group of the next delta-residue in the sequence that seems to stabilize one type of helix over another. Using this structural information, we have inserted two ornithine residues within the helix to install bis-amine functionality. The resulting foldamer acts as a minimalistic aldolase mimic. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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