Tumor vascular heterogeneity and the impact of subtumoral nanoemulsion biodistribution
| Autor: | Jaqueline Vaz de Oliveira, Márcia Cristina Oliveira da Rocha, Ailton Antônio de Sousa-Junior, Mosar Corrêa Rodrigues, Gabriel Ribeiro Farias, Patrícia Bento da Silva, Sônia Nair Bao, Andris Figueiroa Bakuzis, Ricardo Bentes Azevedo, Paulo César Morais, Luís Alexandre Muehlmann, João Paulo Figueiró Longo |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Nanomedicine. 17:2073-2088 |
| ISSN: | 1748-6963 1743-5889 |
| Popis: | Aim: Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 and Ehrlich). Materials & methods: The authors used in vivo image techniques to follow the nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron microscopy to evaluate the tumor structural characteristics. Results & conclusion: Lipid nanoemulsion was delivered to the tumor, vascular organization depends upon the subtumoral localization and this heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical region. Also, the results are presented with a comprehensive mathematical model, describing the differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models. |
| Databáze: | OpenAIRE |
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