Sensitivity of direct smear microscopy for the diagnosis of TB in high HIV prevalent population
| Autor: | Igbasi Uche Thecla, Raheem Toyosi Yekeen, Tochukwu Nwanneka, Onyejepu Nneka, Kunle-Ope Chioma Nneka, Nwokoye Nkiru Nenye, Idigbe Emmanuel Oni, Onubogu Catherine Chizoba, Omoloye Rashidat, Ejezie Clementina Obiageli, Onwujekwe Dan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Case detection Tuberculosis business.industry Population General Engineering Human immunodeficiency virus (HIV) General Physics and Astronomy General Medicine Gold standard (test) medicine.disease_cause medicine.disease Virology General Biochemistry Genetics and Molecular Biology Internal medicine mental disorders medicine Hiv patients Sputum Direct smear medicine.symptom General Agricultural and Biological Sciences education business |
| Zdroj: | Scientific Research and Essays. 7 |
| ISSN: | 1992-2248 |
| Popis: | Diagnosis of tuberculosis (TB) amongst HIV patients is a great challenge due to the low density of Acid Fast bacilli (AFB) in their sputum. The study was conducted to determine the sensitivity of direct smear microscopy (DSM) for TB diagnosis in HIV endemic setting using culture as a gold standard. During the period of study, 549 TB suspects were screened, and they comprised of 396(72%) HIV-positive and 153(28%) HIV-negative patients. Overall, TB positive rate was 221(40.3%), the rate by culture and DSM were 155(28.2%) and 12(2.2%) respectively. Among HIV-positive patients, the overall TB positive rate was 151(38.1%), while the rate by culture and DSM were 120(30.3%) and 7(1.7%) respectively (p = 0.0001). The overall positive rate for HIV-negative was 70(45.8%) and the rate by culture was 35(22.9%) and DSM was 5(3.3%) with p = 0.0004. The sensitivity of DSM in HIV- positive and negative population was 21.5 and 53.8% respectively. Findings from this study showed the low case detection rate of DSM as compared to culture, more especially in HIV positive persons. To improve case detection, we recommend the use of culture as back up to enhance the performance of DSM especially in HIV positive persons. Key words: Tuberculosis, HIV, acid fast bacilli, direct smear microscopy, culture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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