Three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in 2,2,2-trifluoroethanol

Autor:	Samad Khaksar, Saeed Mohammadzadeh Talesh
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Component (thermodynamics) General Chemical Engineering One-pot synthesis General Chemistry Aldehyde Coupling reaction Solvent chemistry.chemical_compound chemistry 2 2 2-Trifluoroethanol Organic chemistry Amine gas treating Ammonium acetate
Zdroj:	Comptes Rendus Chimie. 15:779-783
ISSN:	1631-0748
DOI:	10.1016/j.crci.2012.05.019
Popis:	Trifluoroethanol (TFE) is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of isatoic anhydride, aldehyde and ammonium acetate or primary amine to afford the corresponding 2,3-dihydroquinazolin-4(1 H )-one derivatives in high yields. The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse.
Databáze:	OpenAIRE
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