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The invention of poly(styrene-block-isobutylene-block-styrene) (“SIBS”) was the genius of Joseph P. Kennedy at the University of Akron (Akron, OH, United States). SIBS has no cleavable groups, and its predominantly alternating secondary and quaternary backbone prevents embrittlement and cracking under flexion. This chapter explores four medical devices enabled by SIBS: (1) the world’s most successful drug-eluting stent (TAXUS, Boston Scientific Corporate Research, Marlboro, MA, United States) releases the drug paclitaxel from a SIBS carrier that prevents restenosis by minimizing smooth muscle cell proliferation; (2) the discovery that SIBS provokes insignificant inflammation and encapsulation in the eye led to the development of the PRESERFLO MicroShunt (Santen Pharmaceutical Co. Ltd., Osaka, Japan) to lower intraocular pressure and stop the progression of vision loss from glaucoma; (3) Xi’an EyeDeal Medical Technology Co., Ltd. (Xi’an, China) is developing crosslinked polyisobutylene as an intraocular lens that eliminates glistening and halos; and (4) Polynova Cardiovascular Inc. (Stony Brook, NY, United States) is testing crosslinked SIBS as a heart leaflet valve to allow percutaneous implantation of heart valves in a diverse group of patients. |
