An Electrochemical DNA Sensor for Doxorubicin Based on a Polyelectrolyte Complex and Aminated Thiacalix[4]Arene
| Autor: | K. S. Shibaeva, L. S. Yakimova, Anna Porfireva, Ivan I. Stoikov, G. A. Evtyugin, V. G. Evtyugin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010401 analytical chemistry Cationic polymerization Substrate (chemistry) Polymer 010402 general chemistry Electrochemistry 01 natural sciences Combinatorial chemistry Polyelectrolyte 0104 chemical sciences Analytical Chemistry Dielectric spectroscopy chemistry.chemical_compound chemistry Polyaniline DNA |
| Zdroj: | Journal of Analytical Chemistry. 74:707-714 |
| ISSN: | 1608-3199 1061-9348 |
| Popis: | An impedimetric DNA sensor is developed for the highly sensitive determination of doxorubicin; the signal is charge transfer resistance recorded by electrochemical impedance spectroscopy using a glassy carbon electrode modified by electropolymerized Neutral Red or polyaniline and polyelectrolyte complexes including DNA. The nature of the polymer layer and the composition of the polyelectrolyte complex affect the sensitivity of the determination of doxorubicin. The role of a macrocycle capable of shielding the DNA negative charge and interacting with cationic centers of the substrate is shown. With an optimal composition of polyelectrolytes, the DNA sensor ensures the determination of down to 0.1 nM of doxorubicin. |
| Databáze: | OpenAIRE |
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