ChemInform Abstract: Isoindolines: A New Series of Potent and Selective Endothelin-A Receptor Antagonists
| Autor: | Arco Y. Jeng, Dominick DelGrande, Natalie A. Bilci, Paula Savage, Paivi Jaana Kukkola, Suraj S. Shetty, Theodore Ikler |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | ChemInform. 32 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200147099 |
| Popis: | 1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both the trans and the cis series of isoindolines are discussed. |
| Databáze: | OpenAIRE |
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