A NEW RAT MODEL FOR STUDIES OF HYPOKINESIA AND ANTIORTHOSTASIS

Autor:	X. J. Musacchia, D. R. Deavers
Rok vydání:	1981
Předmět:	medicine.medical_specialty Chemistry medicine.medical_treatment Diuresis Bed rest Surgery Natriuresis Head-Down Tilt Excretion Orthostatic vital signs Endocrinology Hypokinesia Internal medicine Kaliuresis medicine medicine.symptom
DOI:	10.1016/b978-0-08-027340-2.50025-0
Popis:	A new rat model (suspension and immobilization) is described for induction of hypokinesia and orthostatic manipulations. Hypokinetic responses were comparable to those in prolonged bed rest and weightlessness in humans, body or limb casted and small cage restrained animals. Responses to antiorthostasis (15 to 20 deg head down tilt) in rats were similar to those in neutral bouyancy tests in humans and animals and to those in prolonged bed rest in humans. During seven days of hypokinesia there was an atrophy of the gastrocnemius and increased excretion of urinary nitrogeneous end products. The antiorthostatic (AOH) 15 to 20 deg head down tilt resulted in diuresis, natriuresis and kaliuresis. No comparable responses were observed in orthostatic hypokinetic (OH) rats. Readaptation from AOH and OH occurred during one week recovery in metabolic cage conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c240b3ccaf43f7f332a7ff075feae4d3 https://doi.org/10.1016/b978-0-08-027340-2.50025-0 Zobrazit plný text záznamu